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Use SendMessage function with CB_GETDROPPEDSTATE message. If Result is true, then the list box of ComboBox is dropped down. You may send this message every second by using Timer component.

procedure TForm1.Timer1Timer(Sender: TObject);
begin
  if SendMessage(ComboBox1.Handle,CB_GETDROPPEDSTATE,0,0)=1 then
    Caption:='ComboBox is opened'
  else Caption:='ComboBox is closed';
end;

Related topics

Open ComboBox from other control
Detect if user select menu item

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Win32 Programmer's reference

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