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Use GetSystemMetrics function with SM_MOUSEPRESENT parameter.

procedure TForm1.Button1Click(Sender: TObject);
begin
  if GetSystemMetrics(SM_MOUSEPRESENT)<>0 then
    Label1.Caption:='You have a mouse'
  else
    Label1.Caption:='You have not a mouse';
end;

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Detect a wheel of mouse

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Win32 prorammer's referenfe

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