I will tell you in this post how to fix the issue manually and how to clean it automatically using a special powerful removal tool. You can download the removal program for free here:

Malware: C:\sand-box\file.exe

Removed: C:\WINDOWS\system32\srnh.lto

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Detected by UnHackMe:

Item Name: shell
Author: Unknown
Related File: Explorer.exe rundll32.exe srnh.lto iqfnr
Type: System.ini

Removal Results: Success
Number of reboot: 1
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Classification:

Will you remove it?

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People say

Antivirus	Version	Last Update	Result
F-Secure	9.0.15370.0	2010.05.19	Gen:Variant.Oficla.2
Kaspersky	7.0.0.125	2010.05.19	Trojan.Win32.Agent2.cqzi
Microsoft	1.5802	2010.05.18	Trojan:Win32/Oficla.M
NOD32	5129	2010.05.19	Win32/Oficla.GQ

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Installation
When the program is executed, it creates the following registry subkeys and values:

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Keys added:1
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HKLM\Software\Classes\idid

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Values modified:1
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(-) HKLM\Software\Microsoft\Windows NT\CurrentVersion\Winlogon\Shell: “Explorer.exe”
(+) HKLM\Software\Microsoft\Windows NT\CurrentVersion\Winlogon\Shell: “Explorer.exe rundll32.exe srnh.lto iqfnr”

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Files added:2
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C:\Documents and Settings\Administrator\Local Settings\Temp\258.tmp
C:\WINDOWS\system32\srnh.lto

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Files deleted:1
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C:\sand-box\file.exe

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Total changes:5
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Recommended software:
UnHackMe anti-rootkit and anti-malware
http://www.unhackme.com
RegRun Security Suite (Good choice for removal and protection)
http://www.regrun.com

I use UnHackMe for cleaning ads and viruses from my friend's computers, because it is extremely fast and effective.

STEP 1: Download UnHackMe for free

UnHackMe removes Adware/Spyware/Unwanted Programs/Browser Hijackers/Search Redirectors from your PC easily.

UnHackMe is compatible with most antivirus software.
UnHackMe is 100% CLEAN, which means it does not contain any form of malware, including adware, spyware, viruses, trojans and backdoors. VirusTotal (0/56).
System Requirements: Windows 2000-Windows 8.1/10 32 or 64-bit. UnHackMe uses minimum of computer resources.

STEP 2: Double click on UnHackMe_setup.exe

You will see a confirmation screen with verified publisher: Greatis Software.

Once UnHackMe has installed the first Scan will start automatically

STEP 3: Carefully review the detected threats!

Click Remove button or False Positive.

Enjoy!

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Remove Malware

Removed: srnh.lto (trojan Oficla)