Disable Autoplay Mode Requirements Windows 10 build 14965. Pros: Why use this tweak If you want to disable the autoplay of any media, follow this instruction step by step. Cons: Why do not use this tweak? You will have to run all your media manually. How to apply this tweak manually: Open Settings menu. Then go to Devices. Finally go to Autoplay and disable the option "Use autoplay for all media and devices"